Deskripsi
Pfizer
Contents
Apixaban
Indication
Apixaban works by preventing your blood from clotting as quickly or as effectively as normal. It does this by blocking a substance in your blood, called 'factor Xa', which is involved in the development of blood clots.
Instruction
-
Take apixaban exactly as your doctor tells you to. It is taken twice a day, preferably in the morning and the evening. Your doctor or pharmacist will tell you which strength of tablet is right for you as there are two strengths of apixaban available - 2.5 mg and 5 mg. This information will also be printed on the label of the pack to remind you.
-
Apixaban can be taken either with or without food. Swallow the tablet with a drink of water. If you have difficulty swallowing the tablet whole, you can crush the tablet and then mix it with 30 ml (two tablespoons) of water or apple juice, or alternatively, add it to some apple puree. Swallow the mixture as soon as it has been made up.
-
If you forget to take a dose at the usual time, take it as soon as you remember. Try to take the correct number of doses each day, but do not take two doses together to make up for a forgotten dose.
Drug interaction
CYP3A4 & P-gp inhibitors: Increased plasma conc w/ azole antimycotics (eg, ketoconazole, itraconazole, voriconazole & posaconazole) & HIV-PIs (eg, ritonavir); diltiazem, naproxen, amiodarone, verapamil, quinidine. CYP3A4 & P-gp inducers: Decreased plasma conc w/ rifampicin; phenytoin, carbamazepine, phenobarb or St. John's wort. Increased bleeding risk w/ other anticoagulants, platelet aggregation inhibitors & NSAIDs including ASA. Serious bleeding risk w/ thrombolytic agents, GPIIb/IIIa receptor antagonists, thienopyridines (eg, clopidogrel), dipyridamole, dextran & sulfinpyrazone. Reduced exposure w/ activated charcoal.
Lihat detail lebih lanjut tentang Complete Wellness