Hovid Diamide 2.5/500mg

Manufacturer

Hovid

Contents

Glyburide and metformin

Indication
Hovid Diamide contains a combination of glyburide and metformin (400/2.5 mg or 500/5 mg). Glibenclamide and metformin are both oral diabetes medicines that help control blood sugar levels.

Hovid Diamide is used to treat type 2 diabetes. This medicine is not for treating type 1diabetes.

Hovid Diamide may also be used for purposes not listed in this medication guide.

Instruction

• Hovid Diamide should be given with meals and should be initiated at a low dose, with gradual dose escalation as described below, in order to avoid hypoglycemia (largely due to glibenlamide), reduce GI side effects (largely due to metformin), and permit determination of the minimum effective dose for adequate control of blood glucose for the individual patient.

• Use Hovid Diamide as directed by your doctor.

• If you miss a dose, take the missed dose as soon as you remember (be sure to take Hovid Diamide with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Drug interaction

Cimetidine (Tagamet) increases blood levels of Hovid Diamide affecting its metabolism. Hovid Diamide is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Hovid Diamide enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, ACE inhibitors (such as captopril), oxytetracycline, cyclophosphamide and salicylates increase the effects of Hovid Diamide. Decrease of hypoglycemic effect of Hovid Diamide is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates. Azole antifungals (fluconazole) also interact with Hovid Diamide.