Deskripsi
Manufacturer
AstraZeneca
Contents
Omeprazole Mg
Indication
Losec is used for treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used for short-term treatment of ulcers of the stomach or small intestines. It may also be used with certain antibiotics to treat ulcers of the small intestines and to help prevent them from coming back. It may also be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). Losec is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Instruction
Use Losec as directed by your doctor.
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Take Losec by mouth on an empty stomach before eating.
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Swallow Losec whole. Do not break, crush, chew, or open Losec before swallowing.
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If you have trouble swallowing the capsule, add 1 tablespoon of applesauce to an empty bowl. Open the capsule and empty the pellets onto the applesauce. Mix the pellets with the applesauce and swallow the mixture at once, followed by a glass of cool water. The applesauce used should not be hot and should be soft enough to be swallowed with out chewing. Do not chew or crush the pellets. Do not store the mixture for further use.
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You may take antacids while you are using Losec if you are directed to do so by your doctor.
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If you also take an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before taking Losec.
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If you also take sucralfate, take Losec at least 30 minutes before taking sucralfate.
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Continue to take Losec even if you feel well. Do not miss any doses.
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If you miss a dose of Losec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Losec.
Drug interaction
Losec can decreases elimination of diazepam, warfarin and phenytoin. These are medications metabolized in the liver by oxidation. Drugs which are metabolized with help of cytochrome P-450 system (e.g. cyclosporine, disulfiram, benzodiazepines) may also interact with Losec because it is metabolized the same way. Clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with Losec may result in increases in plasma levels of Losec. Concomitant use of Losec and clarithromycin may result in increases in plasma levels of erithromycin, and 14-hydroxy-clarithromycin. You may need additional monitoring of your condition if you are taking ampicillin, cilostazol, cyclosporine, diazepam, digoxin, disulfiram, iron, itraconazole, ketoconazole, moclobemide, phenytoin, sucralfate, vorconizole, or warfarin. This medicine may be combined with antacids if they were prescribed by your doctor. Potent acid-reducing drugs such as Losec diminish the effectiveness of sucralfate, and other medicaitons such as the antifungals ketoconazole and itraconazole. If instructed to take any of these medicines while taking Losec, consult your doctor or pharmacist regarding the proper timing of each dose, usually Losec is taken 30 minutes before sucralfate.
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