Caduet 5/40mg

Manufacturer
Pfizer
 
 
Contents
Per 5 mg/10 mg tab Amlodipine besylate 5 mg, atorvastatin Ca 10 mg. Per 5 mg/20 mg tab Amlodipine besylate 5 mg, atorvastatin Ca 20 mg. Per 5 mg/40 mg tab Amlodipine besylate 5 mg, atorvastatin Ca 40 mg. Per 10 mg/10 mg tab Amlodipine besylate 10 mg, atorvastatin Ca 10 mg. Per 10 mg/20 mg tab Amlodipine besylate 10 mg, atorvastatin Ca 20 mg. Per 10 mg/40 mg tab Amlodipine besylate 10 mg, atorvastatin Ca 40 mg
 
 
Indication
Patients for whom treatment with both amlodipine & atorvastatin is appropriate.
 
Instruction
May be taken with or without food.
 
Drug interaction
Amlodipine: Increased systemic exposure in elderly hypertensive patients w/ diltiazem. Increased plasma conc by strong CYP3A4 inhibitors. Increased risk of hypotension w/ clarithromycin. Lowered plasma conc w/ CYP3A4 inducers. Increased BP-lowering w/ grapefruit juice. Affects trough conc of cyclosporine. Increased tacrolimus blood levels. Atorvastatin: Increased risk of myopathy w/ cyclosporine, fibric acid derivatives, niacin, erythromycin, azole antifungals. Increased plasma conc by CYP450 3A4 inhibitors, protease inhibitors, diltiazem, grapefruit juice. Increased bioavailability w/ OATP1B1 inhibitors. Increased AUC w/ itraconazole. Reduced plasma conc by CYP450 3A4 inducers, Mg- & Al hydroxide-containing antacids, colestipol. Increased digoxin conc. Increased AUC values for norethindrone & ethinyl estradiol. Increased risk of rhabdomyolysis w/ statins. Cases of myopathy w/ colchicine. Severe myositis & myoglobinuria w/ fibrates.