B-cobal

Manufacturer
AV Manufacturing
 
Contents
Mecobalamin 0.5 mg, vit B₁ 100 mg, vit B₆ 200 mg
 
Indication
For neurological and other disorders associated with disturbance of the nerve cell metabolism in which high dose B-complex vitamins play a role. These include: Polyneuritis (of toxic and non toxic etiology): neuralgias eg: lumbago, sciatica, root irritation due to degenerative changes of the vertebral column , shoulder-arm syndrome, herpes zoster, cervical syndrome, ischialgia, etc: diabetic neuropathy; metabolic and neuropathic changes due to pregnancy and oral contraceptives ; convalescence.
Megaloblastic anemia due to vitamin B12 deficiency.
 
Instruction
Usually for adults, orally administer 1 tab 3 times a day.
The dosage should be adjusted according to age of patient and severity of symptoms.
 
Drug interaction
Metformin, histamin H-2 receptor antagonists (cimetidine, ranitidine), aminoglycosides, colchicines, aminosalicylic acid, anticonvulsants, neomycin and alcohol may decrease the absorption of vitamin B12.

Antibiotics, Tetracycline - Vitamin B1 and Vitamin B12 should not be taken at the same time as the antibiotic tetracycline because it interferes with the absorption and effectiveness of this medication. B-cobal tablet should be taken at different times from tetracycline.
 
Antidepressant Medications, Tricylic - Taking vitamin B1 supplements may improve treatment with antidepressants such as nortriptyline, especially in elderly patients. Other medications in this class of antidepressants include desimipramine and imipramine.

Digoxin - Laboratory studies suggest that digoxin may reduce the ability of heart cells to absorb and use vitamin B1. Diuretics particularly furosemide, may reduce the levels of vitamin B1 in the body.
Vitamin B6 decreases the effects of the levodopa