Manufacturer
Abbvie Deutschland GmbH and Co.KG
Contents
Ritonavir
Indication
HIV infection
Instruction
Should be taken with food.
Drug interaction
Increases plasma concentrations of budesonide, fluticasone, rivaroxaban. Increased risk of PR interval prolongation w/ (e.g. digoxin, Ca channel blockers, β-blockers, atazanavir). Reduces plasma concentration of raltegravir.Potentially Fatal: Risk of severe hypotension w/ α1-adrenoreceptor antagonist (alfuzosin). Increased risk of serious resp depression or haematologic abnormalities w/ analgesics (pethidine, piroxicam, dextropropoxyphene). Increased risk of cardiac arrhythmias w/ antiarrhythmics (encainide, amiodarone, bepridil, flecainide, quinidine, propafenone), antihistamines (astemizole and terfenadine) and cisapride. Increases plasma concentrations of antibacterial (fusidic acid), rifabutin (ritonavir dose of 600 mg bid), PDE5 inhibitors [avanafil, sildenafil (when used for the treatment of pulmonary arterial HTN), vardenafil]. Increased risk of haematological abnormalities w/ clozapine and pimozide; risk of coma w/ quetiapine). Risk of extreme sedation and resp depression w/ sedatives/hypnotics (clorazepate, diazepam, estazolam, flurazepam, triazolam, oral midazolam). Increases plasma concentrations of ergot derivatives (ergotamine, dihydroergotamine, ergonovine, methylergonovine) leading to acute ergot toxicity including vasospasm and ischaemia. Increased risk of myopathy (including rhabdomyolysis) w/ statins (lovastatin, simvastatin). Significantly reduces plasma concentration which may lead to loss of antifungal response to voriconazole (ritonavir dose ≥400 mg bid).
Malaysia
