Manufacturer
Actavis Italy S.p.A.
Contents
Phenytoin Na
Indication
Control of tonic-clonic (grand mal) status epilepticus & prevention & treatment of seizures occurring during or following neurosurgery.
Instruction
Status epilepticus Adult 70 kg Loading dose: 10-15 mg/kg slow IV at rate not to exceed 50 mg/min (approx 20 min) followed by maintenance: 100 mg PO or IV every 6-8 hr. Childn & neonate Loading dose: 15-20 mg/kg slow IV at rate not to exceed 1-3 mg/kg/min or 50 mg/min. Neurosurgery Prophylactic dose: 100-200 mg (2-4 mL) IM at approx 4-hr interval during surgery & post-op period.
Drug interaction
Increased serum levels w/ acute alcohol intake, analgesic/anti-inflammatory agents, anesth, antifungals, benzodiapines/psychotropic agents, Ca-channel blockers/CV agents, H2-antagonists, HMG-CoA reductase inhibitors, hormones, immunosuppressants, oral hypoglycemics, proton-pump inhibitors, SSRIs. Decreased serum levels w/ chronic alcohol intake, antiretrovirals, bronchodilators, CV & hyperglycemic agents, folic acid, St. John's wort. Increased or decreased serum levels w/ antibacterials, anticonvulsants, antineoplastics, psychotropic agents. Altered serum levels &/or effects of antibacterials, anticonvulsants, antifungals, antihelmintics, antineoplastics, antiretrovirals, bronchodilators, Ca-channel blockers/CV agents, corticosteroids, coumarin anticoagulants, cyclosporine, diuretics, HMG-CoA reductase inhibitors, hormones, hyperglycemic & neuromuscular blocking agents, opioid analgesics, oral hypoglycemics, psychotropic agents/antidepressants, vit D, folic acid. Decreased serum levels of protein-bound iodine. Increased serum levels of glucose, alkaline phosphatase & γ-glutamyl transpeptidase.
Malaysia
