Manufacturer
Actavis UK Limited
Contents
Glyceryl Trinitrate
Indication
For relief angina pectoris, prophylaxis of angina pectoris and also relief spontaneous coronary artery spasm.
Instruction
Glyceryl trinitrate must be placed under the tongue (administered sublingually) and retained in the mouth until dissolved or discarded. A local burning or tingling sensation may occur.
Drug interaction
Enhanced hypotensive effect w/ vasodilators and other hypotensive drugs. Reduced efficacy (oral/buccal preparations) w/ drugs that cause dry mouth (e.g. TCAs, other antimuscarinics). Increased vasodilatory effect w/ acetylcysteine. May reduce the thrombolytic activity of alteplase. May increase the bioavailability of dihydroergotamine which may lead to coronary vasoconstriction. Potentially Fatal: Potentiation of hypotensive effect w/ PDE5 inhibitors (e.g. sildenafil, tadalafil, vardenafil), riociguat and other organic nitrates w/ nitric oxide (NO) donors. May reduce the anticoagulant effect of heparin.
Malaysia
