Manufacturer
Apex
Contents
Aspirin; Glycine
Indication
Acute ischaemic stroke, Angina pectoris, Myocardial infarction and Prophylaxis of cardiovascular events in high-risk patients
Instruction
Should be taken with food. Acute ischaemic stroke, Angina pectoris, Myocardial infarction
Adult: For primary prevention: Loading: 150-300 mg. Prophylaxis of cardiovascular events in high-risk patients Adult: Long term: 75-150 mg once daily. Short term: 150-300 mg daily.
Drug interaction
Increased risk of GI bleeding and ulceration with corticosteroids. Increased risk of bleeding with coumarin anticoagulants (e.g. heparin, warfarin, phenindione) and antiplatelet agents (e.g. clopidogrel, dipyridamole). May result in severe acidosis and increased CNS toxicity with carbonic anhydrase inhibitors (e.g. acetazolamide). Increases the hypoglycaemic effect of sulfonylureas. Reduces binding of phenytoin and valproate to serum albumin leading to increased free concentration of the drugs. Reduces the effect of uricosurics (e.g. probenecid, sulfinpyrazone). Impairs the renal excretion of lithium and digoxin.Potentially Fatal: Increased risk of GI bleeding and ulceration with other NSAIDs. Increased risk of haematological toxicity of methotrexate.
Malaysia
