Manufacturer
APOTEX INC
Contents
Olanzapine
Indication
Acute & maintenance treatment of schizophrenia & other psychoses where +ve symptoms (eg, delusions, hallucinations, disordered thinking, hostility, & suspiciousness) &/or -ve symptoms (eg, flattened affect, emotional & social w/drawal, poverty of speech) are prominent. Alleviates secondary affective symptoms commonly associated w/ schizophrenia & related disorders. Short-term treatment of acute manic episode & prevention of recurrence of manic, mixed or depressive episodes associated w/ bipolar I disorder.
Instruction
May be taken with or without food: Place in the mouth & allow to disintegrate; it can then be swallowed w/ saliva. Alternatively, disperse in a full glass of water or other beverages (orange juice/apple juice/milk/coffee) immediately prior to taking. Schizophrenia 10 mg/day. Manic episode monotherapy Initially 15 mg as a single daily dose. Combination therapy Initially 10 mg daily. Prevention of recurrence in bipolar disorder Initially 10 mg/day. Dose range: 5-20 mg/day at intervals of not <24 hr.
Drug interaction
Metabolism may be induced by smoking & carbamazepine. May inhibit metabolism w/ fluvoxamine. Decreased bioavailability w/ activated charcoal. May antagonise the effects of direct & indirect dopamine agonists. Other CYP1A2 inhibitors eg, ciprofloxacin or ketoconazole.
Malaysia
