Manufacturer
APOTEX INC
Contents
Amitriptyline HCl
Indication
Nocturnal enuresis,Neuropathic pain, Prophylaxis of migraine, Depression
Instruction
May be taken with or without food.
Drug interaction
May potentiate CV effects of sympathomimetic agents (e.g. adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, phenylpropanolamine). May enhance sedative effects of barbiturates and other CNS depressants. May reduce antihypertensive effects of adrenergic neuron blockers (e.g. guanethidine, betanidine, reserpine, clonidine, methyldopa). May increase ventricular arrythmias with antiarrhythmics (e.g. quinidine, amiodarone), antihistamines (e.g. astemizole, terfenadine), halofantrine, sotalol. Diuretics (e.g. furosemide) may increase risk of hypokalaemia. May increase serum concentrations with antifungals (e.ag. fluconazole, terbinafine). Risk of delirium with disulfiram. Increased rate of metabolism with barbiturates. Increased plasma concentration with cimetidine, methylphenidate, antipsychotics, and Ca-channel blockers. Decreased rate of metabolism with CYP2D6 inhibitors.Potentially Fatal: Increased risk of serotonin syndrome with MAOIs e.g. selegiline, fluoxetine. Increased risk of QT interval prolongation, cardiac arrhythmias with cisapride.
Malaysia
