Manufacturer
APOTEX INC
Contents
Fluconazole
Indication
Oropharyngeal candidiasis, Candiduria, Chronic mucocutaneous candidiasis, Chronic atrophic candidiasis, Dermatophytosis, Candidal balanitis, Vaginal candidiasis, Coccidioidomycosis, Prophylaxis of fungal infections in immunocompromised patients, Cryptococcal meningitis and Invasive candidiasis.
Instruction
May be taken with or without food.
Drug interaction
May increase prothrombin time with anticoagulants (e.g. warfarin). May increase serum concentrations of drugs metabolised by CYP3A4 and CYP2C9 isoenzymes (e.g. bosentan, ciclosporin, midazolam, nevirapine, amitriptyline, nortriptyline, phenytoin, rifabutin, sulfonylurea, nateglinide, celecoxib, parecoxib, tacrolimus, triazolam, zidovudine). May increase risk of myopathy and rhabdomyolysis with HMG-CoA reductase inhibitors (e.g. simvastatin, atorvastatin). May decrease plasma clearance of theophylline. May reduce plasma concentration with rifampicin.Potentially Fatal: Increases the risk of cardiac arrhythmia with drugs known to prolong QT interval or induce torsade de pointes such as astemizole, cisapride, terfenadine, quinidine, pimozide, erythromycin. Increased risk of respiratory depression with fentanyl.
Malaysia
