Manufacturer
APOTEX INC
Contents
Atenolol 100 mg, chlortalidone 25 mg
Indication
Hypertension
Instruction
Per tab contains Atenolol (mg)/Chorthalidone (mg): 50/25 or 100/25. Initially one tab of 50/25 once daily; may increase to one tab of 100/25 once daily according to response.
Drug interaction
Potentiate effects of other antihypertensives. Atenolol: Reduced hypotensive effect with pseudoephedrine, xylometazoline or NSAIDs. Additive effect with calcium antagonist and catecholamine-depleting drugs e.g. reserpine. Increase risk of bradycardia with amisulpride, flecainide, digitalis glycosides. Increase risk of hypotension with alprostadil, baclofen. Withdrawal of clonidine in patients receiving β-blockers may result in rebound hypertension. Chlorthalidone: May alter insulin and dosage of oral hypoglycaemic agents required in diabetics. May reduce renal clearance of lithium and increases risk of lithium toxicity. May cause hypokalaemia therefore increase risk of digitalis toxicity. Risk of hypercalcaemia with paricalcitol. Increased risk of hypokalaemia with ritodrine, amphotericin B. Increased responsiveness to tubocurarine.Potentially Fatal: Atenolol: Bradycardia, heart block may occur when used with verapamil or diltiazem. Severe bradycardia, asystole and heart failure have been reported when used with disopyramide. High degree of cardiac depression may occur with methoxyflurane. Chlorthalidone: Risk of cardiac arrhythmias with ketanserin.
Malaysia
