Manufacturer
ASTELLAS IRELAND CO., LTD.
Contents
Tacrolimus
Indication
Prophylaxis of transplant rejection in adult kidney or liver allograft receipients. Kidney or liver allograft rejection resistant to treatment w/ other immunosuppressive medicinal products in adult patients.
Instruction
Should be taken on an empty stomach: Take at least 1 hr before or 2-3 hr after meals. Swallow whole w/ water.
Drug interaction
Increased blood levels w/ CYP3A4 inhibitors [eg, ketoconazole, fluconazole, itraconazole, voriconazole, erythromycin, HIV PIs (eg, ritonavir); clotrimazole, clarithromycin, josamycin, nifedipine, nicardipine, diltiazem, verapamil, danazol, ethinylestradiol, omeprazole, nefazodone; bromocriptine, cortisone, dapsone, ergotamine, gestodene, lidocaine, mephenytoin, miconazole, midazolam, nilvadipine, norethindrone, quinidine, tamoxifen, (triacetyl) oleandomycin; grapefruit juice; lansoprazol, ciclosporin]. Decreased blood levels w/ CYP3A4 inducers (eg, rifampicin, phenytoin, St. John's wort; phenobarb; carbamazepine, metamizole & INH). Increased or decreased blood levels w/ high-dose prednisolone or methylprednisolone for the treatment of acute rejection. Prolonged t½ of ciclosporin, increased blood level of phenytoin, reduced clearance of steroid-based contraceptives. Potentially decreased clearance & increased t½ of pentobarbital & antipyrine. Increased nephrotoxic or neurotoxic effects w/ aminoglycosides, gyrase inhibitors, vancomycin, co-trimoxazole, NSAIDs, ganciclovir or aciclovir. Enhanced nephrotoxicity w/ amphotericin B & ibuprofen. Risk of hyperkalaemia w/ high K intake or K-sparing diuretics (eg, amiloride, triamterene or spironolactone). Live vaccines.
Malaysia
