Manufacturer
ASTELLAS IRELAND CO., LTD.
Contents
Tacrolimus
Indication
Primary immunosuppression in liver & kidney allograft recipients & liver & kidney allograft rejection resistant to conventional immunosuppressive agents. Recommended to be used concomitantly w/ adrenal corticosteroids. Because of the risk of anaphylaxis, Prograf Injection should be reserved for patients unable to take Prograf capsules only. Lupus nephritis.
Instruction
Should be taken on an empty stomach: Take at least 1 hr before or 2-3 hr after meals. Avoid grapefruit juice.
Drug interaction
Increased blood levels w/ antifungals (eg, ketoconazole, fluconazole, itraconazole, voriconazole), macrolide (erythromycin), HIV PIs (eg, ritonavir); clotrimazole, clarithromycin, josamycin, nifedipine, nicardipine, diltiazem, verapamil, danazol, ethinylestradiol, omeprazole, nefazodone; bromocriptine, cortisone, dapsone, ergotamine, gestodene, lidocaine, mephenytoin, miconazole, midazolam, nilvadipine, norethisterone, quinidine, tamoxifen, troleandomycin; grapefruit juice. Decreased blood levels w/ rifampicin, phenytoin, St. John's wort; phenobarb; carbamazepine, metamizole & INH. Increased or decreased blood levels w/ high-dose prednisolone or methylprednisolone for the treatment of acute rejection. Prolonged t½ of ciclosporin, increased blood level of phenytoin, reduced clearance of steroid-based contraceptives. May potentially decrease clearance & increased t½ of pentobarbital & phenazone. Increased nephrotoxic or neurotoxic effects w/ aminoglycosides, gyrase inhibitors, vancomycin, sulfamethoxazole+trimethoprim, NSAIDs, ganciclovir or aciclovir. Enhanced nephrotoxicity w/ amphotericin B & ibuprofen. Risk of hyperkalaemia w/ high K intake or K-sparing diuretics (eg, amiloride, triamterene or spironolactone). Live vaccines. Oral anticoagulants or antidiabetics.
Malaysia
