Manufacturer
Aurobindo Pharma Limited (Unit XII)
Contents
Per 1.5 g powd for inj Ampicillin Na 1,000 mg, sulbactam Na 500 mg. Per 3 g powd for inj Ampicillin Na 2,000 mg, sulbactam Na 1,000 mg
Indication
Upper & lower resp tract infections eg, sinusitis, otitis media & epiglottitis; bacterial pneumonia; UTI & pyelonephritis; intra-abdominal infections eg, peritonitis, cholecystitis, endometritis & pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone, joint & gonococcal infections. Peri-op prophylaxis for post-op sepsis reduction in abdominal or pelvic surgery & in termination of pregnancy or cesarean section.
Instruction
Adult 1.5-12 g daily in divided doses every 6 or 8 hr up to max: Sulbactam 4 g daily. Less severe infections May be treated every 12 hr. Prophylaxis of surgical infections 1.5-3 g at induction of anesth, may be repeated every 6-8 hr. Uncomplicated gonorrhea 1.5 g as single dose. Childn, infant & neonate 150 mg/kg daily every 6-8 hr. Neonate 1st wk of life 75 mg/kg daily in divided doses every 12 hr.
Drug interaction
Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation w/ aminoglycosides. Additive effects w/ anticoagulants. Interfered bactericidal effects by bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides & tetracyclines. Reduced effectiveness of estrogen-containing OCs. Decreased clearance & toxicity of methotrexate. Decreased renal tubular secretion by probenecid. False +ve glycosuria test.
Malaysia
