Thrombolytic treatment in acute MI (AMI): 90-min (accelerated) dose regimen for patients in whom treatment can be started w/in 6 hr of symptom onset; 3-hr dose regimen for patients in whom treatment can be started between 6-12 hr after symptom onset. Thrombolytic treatment in acute massive pulmonary embolism w/ haemodynamic instability. Thrombolytic treatment of acute ischaemic stroke to be initiated w/in 4.5 hr after the onset of stroke symptoms & after exclusion of intracranial hemorrhage by appropriate imaging techniques eg, cranial computerised tomography (CT) or other diagnostic imaging method sensitive for the presence of haemorrhage.