Manufacturer
INTAS PHARMACEUTICALS LIMITED
Contents
Bisoprolol fumarate
Indication
Stable chronic heart failure w/ reduced systolic left ventricular function in addition to ACE inhibitors, diuretics & optional cardiac glycosides. 5 & 10 mg: HTN, CHD (angina pectoris).
Instruction
May be taken with or without food.
Drug interaction
May potentiate atrioventricular conduction time and may increase negative inotropic effect with class I antiarrhythmic drugs (e.g. quinidine, disopyramide, propafenone). Concomitant use with calcium antagonists (e.g. verapamil, diltiazem) may lead to atrioventricular block and profound hypotension. Concomitant catecholamine-depleting drugs (e.g. reserpine, guanethidine) may produce excessive reduction of sympathetic activity. Heart failure may worsen when given with centrally acting antihypertensives (e.g. clonidine, methyldopa). Increased risk of bradycardia with digitalis glycosides. Coadministration with rifampicin increases metabolic clearance of bisoprolol. Reduced hypotensive effect with NSAIDs.
Malaysia
