Manufacturer
INTAS PHARM LTD
Contents
Methotrexate
Indication
Choriocarcinoma/ Mycosis fungoides/ Acute lymphoblastic leukaemia/ Crohn's disease/ Osteosarcoma/ Meningeal leukaemia/ Breast cancer/ Advanced lymphosarcoma/ Acute lymphoblastic leukaemia/ Psoriasis
Instruction
Administer via IV/IM
Drug interaction
Decreased effectiveness with folic acid and its derivatives.Potentially Fatal: Increased toxicity with NSAIDs and salicylates; probenecid; some penicillins; aminoglycosides neomycin and paromomycin; sulfonamides such as sulfafurazole and sulfamethoxazole; co-trimoxazole or trimethoprim; nephrotoxic agents (e.g. cisplatin); ciclosporin; etretinate. Synergistic enhancement of effects with fluorouracil. Increased bioavailability of mercaptopurine. Reduces serum-valproate concentrations. Reduced serum concentrations with colestyramine. Increased serum concentrations with omeprazole.
Malaysia
