Manufacturer
RECKITT BENCKISER HEALTHCARE (UK) LTD
Contents
Buprenorphine HCl
Indication
Premedication before anaesthesia, Perioperative analgesic supplement, Moderate to severe pain,
Instruction
Administer via IM, slow IV and Parenteral
Drug interaction
Plasma-buprenorphine concentrations may be affected when co-administered w/ drugs that induce or inhibit CYP3A4 isoenzyme. Enhanced depressant effects of other CNS depressants, other opiate agonists, anaesth, antihistamines, muscle relaxants, tranquilisers (e.g. phenothiazines), sedatives and hypnotics (e.g. benzodiazepines). Increased and/or prolonged activity w/ drugs that may reduce hepatic blood flow (e.g. halothane). Receiving class IA (e.g. quinidine, procainamide) or class III (e.g. sotalol, amiodarone) antiarrhythmic agents w/ transdermal buprenorphine may increase the risk of QT interval prolongation.Potentially Fatal: Concomitant admin of IV buprenorphine and oral diazepam may produce resp and CV collapse. MAOIs may be additive w/ or may potentiate action of CNS depressants.
Malaysia
