Manufacturer
SM PHARMACEUTICALS SDN. BHD.
Contents
Fluconazole
Indication
Cryptococcosis ie, cryptococcal meningitis & infections of other sites eg, pulmonary, cutaneous. Maintenance therapy to prevent relapse of cryptococcal disease in patients w/ AIDS. Systemic candidiasis ie, candidemia, disseminated candidiasis & other forms of invasive candidal infection. Mucosal candidiasis ie, oropharyngeal, esophageal, non-invasive bronchopulmonary infections, candiduria, mucocutaneous & chronic oral atrophic candidiasis (denture sore mouth). Prevention of oropharyngeal candidiasis relapse in patients w/ AIDS. Acute or recurrent genital & vag candidiasis. Prophylaxis to reduce incidence of recurrent vag candidiasis. Candidal balanitis. Prevention of fungal infections in patient w/ malignancy predisposed to such infections as a result of cytotoxic chemo- or radiotherapy. Dermatomycosis ie, tinea pedis, corporis & cruris, pityriasis versicolor & candida infections.
Instruction
May be taken with or without food.
Drug interaction
Increased prothrombin time w/ coumarin-type anticoagulants. Prolonged serum t½ of sulfonylureas eg, chlorpropamide, glibenclamide, glipizide & tolbutamide. Increased plasma conc w/ hydrochlorothiazide. Increased phenytoin, zidovudine levels. Decreased AUC & t½ w/ rifampicin. Increased cyclosporin conc. Decreased plasma clearance of theophylline. Serious cardiac dysrhythmias secondary to prolonged QTc interval w/ terfenadine. Cardiac events eg, Torsade de pointes w/ cisapride. Increased serum levels of rifabutin, tacrolimus, cisapride, astemizole or CYP450-metabolized drugs.
Malaysia
