Manufacturer
SM PHARMACEUTICALS SDN. BHD.
Contents
Per combi pack: 14 Claritrox tab each containing Clarithromycin 250 mg, 14 Metgyl tab each containing Metronidazole 400 mg, 14 Omilock cap each containing Omeprazole 20 mg
Indication
Peptic ulcer associated w/ H pylori.
Instruction
Should be taken on an empty stomach.
Drug interaction
Claritrox Increased plasma conc of carbamazepine & terfenadine. Increased serum digoxin conc. Decreased serum conc w/ rifabutin or rifampin. Increased AUC of theophylline. Potentiated effects of warfarin. Acute ergot toxicity w/ ergotamine or dihydroergotamine. CNS effects w/ triazolam. Increased serum levels of cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, quinidine/disopyramide, lovastatin, bromocriptine, valproate, astemizole & CYP450-metabolised drugs. Ventricular arrhythmias w/ non-sedative antihistamines eg, astemizole, terfenadine & cisapride. Lowered Cmax, AUC & delayed Tmax w/ zidovudine. Metgyl Disulfiram-like effects w/ alcohol. Potentiated effects of coumarin- or indandione-derivative anticoagulants. Decreased hepatic metabolism w/ cimetidine. Confusion & psychotic reaction w/ disulfiram. Increased lithium conc. Decreased t½ & plasma conc w/ phenobarb. Increased plasma conc of phenytoin. Spuriously low values on aspartate aminotransferase assay. Omilock Increased bioavailability of digoxin. Increased plasma conc of diazepam, phenytoin & warfarin.
Malaysia
