Manufacturer
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Contents
Alogliptin + Metformin
Indication
Type 2 diabetes mellitus.
Instruction
Should be taken with food.
Drug interaction
Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oral contraceptives, sympathomimetics, phenytoin, nicotininc acid, Ca channel blockers and isoniazid may produce hyperglycaemia which may lead to loss of glycaemic control.Alogliptin: Increased risk of hypoglycaemia when used in combination with sulfonylureas or insulin.Metformin: Concomitant cationic drugs that interfere with renal tubular transport systems (e.g. ranolazine, vandetanib, dolutegravir, cimetidine) may increase metformin levels. Increased risk of lactic acidosis with topiramate or other carbonic anhydrase inhibitors (e.g. zonisamide, acetazolamide, dichlorphenamide), ACE inhibitor, angiotensin II receptor antagonists, NSAIDs, loop diuretics. May impair vitamin B12 absorption.Potentially Fatal: Intravascular admin of iodinated contrast agents may cause renal dysfunction, leading to metformin-induced lactic acidosis.
Malaysia
