Manufacturer
XEPA-SOUL PATTINSON (MALAYSIA) SDN BHD
Contents
Hydrochlorothiazide
Indication
Oedema, Hypertension
Instruction
Should be taken with food.
Drug interaction
Increases toxicity of lithium. Risk of hypokalaemia may be increased when given with drugs that induce torsades de pointes e.g. digitalis glycoside, astemizole, sotalol, terfenadine, pimozide. May enhance orthostatic hypotension with barbiturates and opioids. Additive effect and may enhance first-dose hypotension with α-blockers and ACE inhibitors. Cholestyramine and colestipol resins may reduce absorption of hydrochlorothiazide. Increased K-depleting effect with corticosteroids, ACTH and amphotericin B. May increase response to neuromuscular blocking action of skeletal muscle relaxants (e.g. tubocurarine). May reduce diuretic and antihypertensive effects of diuretics with NSAIDs. May reduce the therapeutic effect of antidiabetics. May decrease excretion thereby increasing toxicity of amines (e.g. amphetamine, quinidine).
Malaysia
