Manufacturer
Fresenius Kabi Manufacturing SA (Pty) Ltd.
Contents
Morphine sulphate
Indication
Symptomatic relief of moderate to severe pain, especially associated w/ neoplastic disease, MI & surgery. Adjunctive therapy in acute pulmonary oedema secondary to left ventricular failure.
Instruction
Analgesic Adult IM or SC Initially 10 mg every 4 hr as needed. Dose range: 5-20 mg. Slow IV 4-10 mg diluted in sterile water for inj 4-5 mL. Epidural 5 mg w/ incremental doses of 1-2 mg/hr if needed up to max: 10 mg/24 hr. Intrathecal 0.2-1 mg/kg as single dose. Paed SC 0.1-0.2 mg/kg every 4 hr as needed. Max: Not to exceed 15 mg/dose. Very slow IV 0.05-0.1 mg/kg. Pre-op 0.05-0.1 mg/kg IM. Max: Not to exceed 10 mg/dose.
Drug interaction
Enhanced depressant effects w/ CNS depressants eg, alcohol, anaesth, hypnotics & sedatives, TCAs, phenothiazines. Precipitated w/drawal symptoms w/ opioid analgesics eg, buprenorphine, butorphenol, nalbuphine or pentazocine. Delayed mexiletine absorption. Counteracted metoclopramide effects.
Malaysia
