Manufacturer
Fresenius Kabi Oncology Limited (XI Route)
Contents
Docetaxel
Indication
Breast cancer and Gastric adenocarcinoma, Head and neck cancer, Non-small cell lung cancer, Prostate cancer.
Instruction
Breast cancer
Adult: 60-100 mg/m2 by infusion over 1 hr once every 3 wk. In combination w/ doxorubicin or capecitabine or as adjuvant therapy w/ doxorubicin and cyclophosphamide: 75 mg/m2 once every 3 wk. In combination w/ trastuzumab: 100 mg/m2 once every 3 wk.
Gastric adenocarcinoma, Head and neck cancer, Non-small cell lung cancer, Prostate cancer
Adult: 75 mg/m2 by infusion over 1 hr once every 3 wk. For gastric adenocarcinoma: Dose is given before cisplatin and fluorouracil. For head and neck cancer: Given before cisplatin and fluorouracil for 3 cycles followed by chemoradiotherapy or 4 wk followed by radiotherapy alone. For prostate cancer: May be given w/ oral prednisolone 5 mg bid continuously during treatment.
Drug interaction
CYP3A4 inducers, inhibitors, or substrates may alter docetaxel metabolism.
Malaysia
