Manufacturer
Servier
Contents
Per 4 mg/1.25 mg tab Perindopril arginine 4 mg, indapamide 1.25 mg.
Indication
Essential Hypertension.
Instruction
Should be taken on an empty stomach: Preferably taken in the morning before a meal.
Drug interaction
Reversible increased serum conc & toxicity of lithium. Increased antihypertensive effect w/ baclofen. Attenuated antihypertensive effect w/ NSAIDs ie, acetylsalicylic acid, COX-2 inhibitors. Increased antihypertensive effect & risk of orthostatic hypotension w/ TCAs, neuroleptics. Increased risk of hyperkalaemia w/ aliskerin, K salts, K-sparing diuretics, ACE inhibitors, angiotensin-II receptor antagonists, NSAIDs, heparins, immunosuppresants eg, ciclosporin or tacrolimus, trimethoprim; co-trimoxazole. Increased risk of hyperkalaemia, worsened renal function, CV morbidity & mortality w/ aliskerin. Increased risk of severe anaphylactoid reactions w/ extracorporeal treatments eg, dialysis or haemofiltration. Increased risk of angioneurotic oedema w/ estramustine. Additive hyperkalaemic effects w/ K-sparing diuretics (eg, triamterene, amiloride), K salts. Increased BP-lowering effect w/ antidiabetic agents eg, insulin, oral hypoglycaemic agents. Reduced hypotensive effects w/ non-K-sparing diuretics. Increased risk of angioedema w/ racecadotril, mTOR inhibitors (eg, sirolimus, everolimus, temsirolimus), gliptins (eg, linagliptin, saxagliptin, sitagliptin, vildagliptin); sacubitril/valsartan. Increased hypotensive effects by antihypertensives & vasodilators. Reduced BP w/ nitroglycerin & other nitrates or other vasodilators. Increased risk of leucopenia w/ allopurinol, cytostatic or immunosuppressive agents, systemic corticosteroids or procainamide. Enhanced hypotensive effects w/ anaesth drugs. Reduced antihypertensive effects w/ sympathomimetics, corticosteroids & systemic tetracosactide. Nitritoid reactions w/ injectable gold (Na aurothiomalate). Risk of hypokalemia w/ Torsade de pointes-inducing drugs eg, class IA & III antiarrhythmic agents, some neuroleptics, benzamides, butyrophenones, other neuroleptics; bepridil, cisapride, diphemanil, IV erythromycin, halofantrine, mizolastine, moxifloxacin, pentamidine, sparfloxacin, IV vincamine, methadone, astemizole, terfenadine. Increased risk of low K levels by IV amphotericin B, glucocorticoids, systemic mineralocorticoids, tetracosactide, stimulant laxatives. Increased hypersensitivity reactions to allopurinol. Favoured toxic effects of digitalis. Lactic acidosis due to metformin. Increased risk of acute renal insufficiency w/ high-dose iodinated contrast media. Reduced urine Ca elimination. Increased creatinine levels w/ ciclosporin, tacromilus.
Malaysia
