Manufacturer
GlaxoSmithKline Manufacturing S.p.A
Contents
Fentanyl
Indication
Premedication before anaesthesia, Adjunct to general anaesthesia
Instruction
IV Adjunct to general anaesthesia Patients w/ spontaneous respiration: Initial: 50-200 mcg followed by supplements of 50 mcg. Max: 200 mcg. Admin lower infusion rates of 0.05-0.08 mcg /kg/min. Patients w/ assisted ventilation: Initial: 300-3,500 mcg (up to 50 mcg/kg) followed by supplements of 100-200 mcg depending on response. Loading dose (alternatively via bolus): Approx 1 mcg/kg/min given for the 1st 10 min followed by infusion of approx 100 ng/kg/min. IM Premedication before anaesthesia 50-100 mcg to be given 30-60 min prior to induction of anaesth.
Drug interaction
Concomitant use w/ CYP3A4 inhibitors (e.g. erythromycin, clarithromycin, troleandomycin, azole antifungals, ritonavir, amiodarone, nefazodone, aprepitant, diltiazem and verapamil) increases serum levels of fentanyl and may potentiate fatal resp depression. Increased risk of life-threatening serotonins syndrome w/ SSRIs, SNRIs and MAOIs. May reduce serum levels w/ rifamycin derivatives. Enhanced depressant effect w/ general anaesth, tranquilisers, barbiturates and narcotics. May increase excretion w/ ammonium Cl. May increase hypotensive effect w/ phenothiazines. May reduce efficacy of pegvisomant.
Malaysia
