Lanoxin Injection 0.5mg/2ml

Manufacturer
GlaxoSmithKline Manufacturing S.p.A
 
Contents
Digoxin
 
Indication
Management of chronic cardiac failure where systolic dysfunction is dominant: Patients w/ ventricular dilatation; cardiac failure w/ atrial fibrillation. Management of supraventricular arrhythmias particularly chronic atrial flutter & fibrillation.
 
Instruction
Adult: For patients who have not received cardiac glycosides in the previous 2 weeks. Dosage is individualised according to age, lean body weight and renal status. Loading dose of 500-1,000 mcg (0.5-1 mg) by IV infusion over a period of 10-20 minutes in divided doses with approx half of the dose given as first dose and further fractions of the total dose given every 4-8 hours.
Child: Loading dose: Preterm neonates <1.5 kg: 25 mcg/kg/day; 1.5-2.5 kg: 30 mcg/kg/day. Term neonates-2 years 45 mcg/kg/day; >2-5 years 35 mcg/kg/day; >5-10 years 25 mcg/kg/day. Maintenance: Preterm neonates 20% of 24-hour loading dose; Term neonates and children up to 10 years 25% of 24-hour loading dose.
Elderly: Dosage reductions may be needed.
 
Drug interaction
Concomitant use w/ β-adrenoreceptor blocking may increase atrioventricular conduction time. Increased sensitivity to digoxin w/ agents causing hypokalaemia or intracellular K deficiency eg, diuretics, lithium salts, corticosteroids & carbenoxolone. Increased susceptibility to suxamethonium-exacerbated hyperkalaemia. Serious arrhythmias in digitalized patients w/ IV Ca. Increased serum levels w/ concomitant use of amiodarone, flecainide, prazosin, propafenone, quinidine, spironolactone, macrolides (eg, erythromycin, clarithromycin, tetracyclines), gentamicin, itraconazole, quinine, trimethoprim, alprazolam, indomethacin, propantheline, efazodone, atorvastatin, cyclosporine, epoprostenol (transient), tolvaptan, carvedilol, verapamil, felodipine, tiapamil. Reduced levels w/ concomitant use of antacids, some bulk laxatives, kaolin-pectin, acarbose, neomycin, penicillamine, rifampicin, some cytostatics, metoclopramide, sulfasalazine, adrenaline, salbutamol, cholestyramine, phenytoin, St. John's wort.