Manufacturer
PFIZER (PERTH) PTY. LTD.
Contents
Cisplatin
Indication
Monotherapy or in combination w/ other chemotherapeutic agents for metastatic non-seminomatous germ cell carcinoma, advanced stage refractory ovarian & bladder carcinoma, refractory squamous cell head & neck carcinoma.
Instruction
Adult & childn Monotherapy 50-100 mg/m2 as single IV infusion every 3-4 wk over 6-8 hr or 15-20 mg/m2 slow IV infusion daily for 5 days every 3-4 wk. Testicular cancer In combination w/ vinblastine, bleomycin, actinomycin D. Ovarian cancer In combination w/ cyclophosphamide, doxorubicin, hexamethylmelamine, 5-fluorouracil. Head & neck cancer In combination w/ bleomycin, methotrexate.
Drug interaction
Exacerbated nephrotoxic & ototoxic effects w/ aminoglycosides or loop diuretics. Black precipitate w/ Al. Concomitant use w/ live vaccines.
Malaysia
