Manufacturer
PHARMANIAGA LIFESCIENCE SDN. BHD.
Contents
Leucovorin Ca
Indication
Certain megaloblastic anaemia resulting from folic acid deficiency in infant, during pregnancy, in malabsorption syndromes, liver diseases, sprue & malnutrition. Reducing toxicity & circumventing effect of folic acid antagonists.
Instruction
Leucovorin rescue after methotrexate therapy 15 mg every 6 hr for 10 doses 24 hr after start of methotrexate infusion. Normal methotrexate elimination 15 mg orally, IM or IV every 6 hr for 60 hr (10 doses starting at 24 hr after start of methotrexate infusion). Delayed methotrexate elimination Continue 15 mg orally, IM or IV every 6 hr until methotrexate level is <0.05 micromolar. Impaired methotrexate elimination or inadvertent overdosage 10 mg/m2 IV, IM or orally every 6 hr, may be increased to 100 mg/m2 IV every 3 hr until serum methotrexate level is <10-8M. Megaloblastic anaemia Up to 1 mg daily. Pyrimethamine overdosage 3-9 mg daily IM for 3 days or until platelet & leucocyte counts reached safety.
Drug interaction
Counteracted phenobarb, phenytoin, primidone antiepileptic effect in large doses. Reduced efficacy of intrathecal methotrexate. Enhanced fluorouracil toxicity. Incompatible w/ droperidol & phosphonosulphate.
Malaysia
