Manufacturer
PHARMANIAGA LIFESCIENCE SDN. BHD.
Contents
Phenytoin Na
Indication
Control of tonic-clonic (grand mal) status epilepticus. Prevention & treatment of seizures during or following neurosurgery.
Instruction
Status epilepticus Adult Loading dose: 10-15 mg/kg slow IV at a rate not exceeding 50 mg/min. Maintenance dose: 100 mg orally/IV every 6-8 hr. Childn Loading dose: 15-20 mg/kg slow IV at a rate not exceeding 1-3 mg/kg/min. Neurosurgery prophylaxis 100-200 mg IM at approx 4-hr intervals during & post-op.
Drug interaction
Increased serum levels w/ acute alcohol intake, analgesic/anti-inflammatory agents, anesth, antifungals, benzodiapines/psychotropic agents, Ca-channel blockers/CV agents, H2-antagonists, HMG-CoA reductase inhibitors, hormones, immunosuppressants, oral hypoglycemic agents, proton-pump inhibitors, SSRIs. Decreased serum levels w/ chronic alcohol intake, antiretrovirals, bronchodilators, CV agents, folic acid, hyperglycemic agents, St. John's wort. Increased or decreased serum levels w/ antibacterials, anticonvulsants, antineoplastics, psychotropic agents. Altered serum levels &/or effects of antihelmintics, corticosteroids, coumarin anticoagulants, cyclosporine, diuretics, hyperglycemic & neuromuscular-blocking agents, opioid analgesics, psychotropic agents/antidepressants, vit D. Decreased serum levels of protein-bound iodine. Increased serum levels of glucose, alkaline phosphatase & γ-glutamyl transpeptidase.
Malaysia
