Manufacturer
PHARMANIAGA MANUFACTURING BERHAD
Contents
Allopurinol
Indication
Gout, Hyperuricaemia, Cancer therapy-induced hyperuricaemia, Recurrent calcium oxalate stones.
Instruction
Gout, Hyperuricaemia
Adult: Initially, 100 mg daily, then adjusted according to serum urate concentration. Maintenance: Mild: 100-300 mg daily; moderately severe: Up to 600 mg daily. Max: 900 mg/day. Doses over 300 mg daily should be taken in divided doses.
Cancer therapy-induced hyperuricaemia
Adult: 600-800 mg daily in divided doses, 2-3 days before cancer treatment.
Child: <15 yr 10-20 mg/kg daily. Max: 400 mg/day.
Recurrent calcium oxalate stones
Adult: 200-300 mg daily in single or divided doses.
Drug interaction
May inhibit the metabolism of mercaptopurine and azathioprine; reduce dose of mercaptopurine and azathioprine when given w/ allopurinol. May increase effect of warfarin and other coumarin anticoagulants. Increased excretion of the oxipurinol (metabolite) w/ salicylates or uricosuric agents. Increased toxicity w/ thiazide diuretics, some antibacterials, other antineoplastics, ciclosporin, some sulfonylurea antidiabetics, theophylline and vidarabine.
Malaysia
