Manufacturer
DUOPHARMA MANUFACTURING (BANGI) SDN BHD
Contents
Tetracycline
Indication
Susceptible infections, Acne vulgaris, Rosacea, Brucellosis, Nongonococcal urethritis, Uncomplicated genital infections due to Chlamydia trachomatis, Uncomplicated gonorrhoea, Syphilis, Epididymo-orchitis,
Instruction
Should be taken on an empty stomach. Take 1 hr before or 2 hr after meals w/ a full glass of water, in upright position. May be taken w/ meals to reduce GI discomfort.
Drug interaction
Absorption may be impaired by divalent and trivalent cations (e.g. Al, Ca, Mg, Fe, Zn), Na bicarbonate, bismuth subsalicylate, kaolin-pectin, sucralfate, colestipol and colestyramine. May form a complex with strontium ranelate, resulting in decreased absorption of tetracycline. May interfere with the bactericidal action of penicillin. May prolong the effect of anticoagulants. May reduce plasma-atovaquone concentration. May decrease the efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients with diabetes mellitus. May increase the toxic effects of ergot alkaloids and methotrexate. May increase lithium and digoxin levels. May diminish therapeutic effects of BCG, BCG vaccine, typhoid vaccine.Potentially Fatal: Increased risk of benign intracranial hypertension when given concurrently with retinoids (e.g. acitretin, tretinoin, isotretinoin). Concurrent use of methoxyflurane may result in renal toxicity.
Malaysia
