Amoxicillin and Clavulanate Potassium for Injection 1.2g

Manufacturer
HEALOL PHARMACEUTICALS SDN. BHD.
 
Contents
Amoxicillin Na 1,000 mg, K clavulanate 200 mg
 
Indication
Short-term treatment for upper & lower resp tract, skin & soft tissue, bone & joint & dental infections, septic abortion, puerperal & intra-abdominal sepsis, septicaemia, peritonitis & post-op infections. Prophylaxis against infections in major surgery.
 
Instruction
Adult & childn >12 yr 1.2 g 8 hrly. More serious infections Increase to 6 hrly intervals. Childn 3 mth-12 yr 30 mg/kg 8 hrly. More serious infections Increase to 6 hrly intervals. Childn 0-3 mth 30 mg/kg 12 hrly increase to 8 hrly thereafter. Surgical prophylaxis Adult Usual dose: 1.2 g at induction of anesth; high risk of infection 3-4 doses of 1.2 g in 24-hr period. Moderate renal impairment (CrCl 10-30 mL/min) 1.2 g IV followed by 600 mg IV 12 hrly. Severe renally impaired adult (CrCl <10 mL/min) 1.2 g IV followed by 600 mg IV 24 hrly.
 
Drug interaction
Increased & prolonged blood levels w/ probenecid. Increased allergic skin reactions w/ allopurinol. Lowered oestrogen reabsorption & reduced efficacy of combined OCs.