Penerangan
Manufacturer
Novartis
Contents
Amlodipine besylate 5 mg, valsartan 80 mg
Indication
Essential HTN where BP is not adequately controlled by monotherapy
Instruction
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Take Exforge exactly as your doctor tells you to. You may be asked to take Exforge once or twice a day depending on the reason why you are taking it. When you first start treatment, your doctor may gradually increase the strength of your dose to suit your condition. There are several different strengths of tablet/capsule available, so each time you collect a fresh supply, it's a good idea to check the strength on the packet to make sure they are what you are expecting.
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Try to take Exforge at the same time(s) of day each day. Taking your doses at the same times will help you to remember to take Exforge regularly.
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Swallow the tablet/capsule with a drink of water. You can take Exforge either before or after a meal.
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If you forget to take a dose, take it as soon as you remember. If when you remember, it is nearly time for your next dose then take your next dose when it is due but leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Drug interaction
Amlodipine: Increased exposure of simvastatin. Increased plasma conc w/ CYP3A4 inhibitors. Valsartan: Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K or other drugs that increase K levels. Concomitant use of angiotensin II antagonist w/ NSAIDs may attenuate antihypertensive effects. Furthermore, increase worsening of renal function in vol-depleted or w/ compromised renal function elderly patients. Co-administration of inhibitors of uptake transporter (rifampin, ciclosporin) or efflux transporter (ritonavir) may increase systemic exposure to valsartan.
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