WELLNESS NMN 500MG 15Sachet x 2 (EXP 05/2027)

<article class=''lzd-article'' style=''white-space:break-spaces''><h2 style=''font-size:16pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(0, 0, 0);font-size:16pt''>The ultimate solution to anti-ageing</span></h2><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span></span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Whitening and UV protection effects</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>NMN has been recognized as a cosmetic ingredient for its firmness and luster, and it is thought that supplementing NMN can improve the condition of the skin. Effepharm is applying for a patent while conducting UV tests on the skin with NMN. We plan to publish an SCI treatise in the future.</span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Improvement of cognitive function and memory</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Alzheimers disease is caused by the deposition of amyloid peptide (A). NMN reduced the accumulation of ROS in hippocampal sections of amyloid peptide by restoring NAD + and ATP. Studies have shown that cognitive function in AD model mice has been restored.</span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Promotion of blood circulation and improvement of heart function</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Research studies have shown that NMN has the potential to prevent local ischemia. IPC stimulates SIRT1 and Sirt1 supports the delivery of blood throughout the body as a NAD + -dependent protein deacetylase. By activating Sirt1, NMN protects the heart and prevents ischemia and reperfusion.</span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Brain activation and prevention of neurological disorders</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Having healthy and active mitochondria makes you less susceptible to neurodegenerative diseases. NMN is likely to help prevent neurodegenerative diseases by increasing NAD + levels and increasing mitochondrial activity levels.</span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Obesity control and fat burning effect</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>NMN works on the metabolism of adipose tissue and has the effect of burning the fat accumulated in the body. In a study, NMN intake improved insulin secretion, increased adiponectin, and showed a significant decrease in free fatty acids (FFA).</span></p><h1 style=''font-size:20pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(12, 113, 195);font-size:15pt''>Suppression of aging and activation of cells</span></h1><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>NAD + levels decrease with age. Studies have shown that NMN is enzymatically converted to NAD. When NMN activates the sirtuin gene, NAD + increases, which can be expected to improve physical function and suppress aging.</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span></span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:11pt''>Uthever NMN 's strengths</span></p><h2 style=''font-size:16pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:11pt''>Top quality guarantee</span></h2><ul style=''list-style-type:disc''><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Good absorption efficiency, easier to feel the effect</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>High purity of 99% or more</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Equipped with a clean room at the pharmaceutical manufacturing level</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Obtaining Kosher certification</span></div></li></ul><h2 style=''font-size:16pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:11pt''>High safety</span></h2><ul style=''list-style-type:disc''><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>The United States Food and Drug Administration (FDA) of the GRAS carefully selected raw materials from the authentication program</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Certification of high-purity raw materials by inspection agencies</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Publication of LC-MS, HPLC analysis report by the largest American analysis organization (Agilent Technology)</span></div></li></ul><h2 style=''font-size:16pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:11pt''>Reduction of production loss</span></h2><ul style=''list-style-type:disc''><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Excellent stability even at room temperature</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Made-to-order manufacturing system that can handle various dosage forms</span></div></li></ul><h2 style=''font-size:16pt;line-height:1.45;margin-top:11pt;margin-bottom:11pt;text-align:left;text-indent:0;margin-left:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:11pt''>Global brand power</span></h2><ul style=''list-style-type:disc''><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Conducting the worlds only human clinical trial</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Top level R & D team</span></div></li><li><div style=''line-height:1.7;text-align:left;text-indent:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);font-size:12pt''>Achievements deployed in 16 countries around the world</span></div></li></ul><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>With so many scientific reports on animals,Effepharmdecided to conduct our own clinical study on Uthever.nOur clinical study would start from:</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>(1) Safety assessmentn(2) Anti-agingn(3) Boosting energy and increasing endurance</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>The clinical study on Utheveris registered in the US and WHOs official clinical registry system and displayed on the websites to the public.</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Title: Evaluate the Efficacy and Safety of Uthever NMN(</span><span style=''font-weight:bold;color:rgb(0, 0, 0);background-color:transparent;font-size:10.5pt''>Nicotinamide Mononucleotide</span><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>, a Form of Vitamin B3)</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Official Title: A Multicentre, Randomized, Double-Blind, Parallel Design, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Uthever(NMN), an Orally Administered Supplementation in Middle-Aged and Older Adults.</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>US register ID: NCT04228640</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Study Type: Interventional (Clinical Trial)</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Estimated Enrollment: 66 participants</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Allocation: Randomized</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Intervention Model: Parallel Assignment</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Intervention Model Description: A Multicenter, Randomized, Double-Blind, Placebo-Controlled</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Primary Purpose: Prevention</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>To assess its safety, physical examination, blood biochemistry test, BMI, and HOMA will be performed at baseline and end of the study. Blood cellular NAD+ and NADH concentration in serum will de determined to confirm its ability to increase NAD levels in the human body.</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>Effepharmis proud to be the first and the only</span><span style=''font-weight:bold;color:rgb(0, 0, 0);background-color:transparent;font-size:10.5pt''>NMN Manufacturer</span><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>in the world to conduct clinical trials. The clinical study on Utheveris the largest scale in the world according to WHOs the clinical database.</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''>UTHEVERs clinical trial report has been published on the frontier in aging. : The rise in the levels of NAD+/NADH at day 30 and day 60 illustrated the potential of Uthever to raise the levels of NAD+ in the cells, which is linked to higher energy levels and an anti-aging effect. Increased sensitivity to insulin has also been linked to antiaging. There was no noteworthy change in HOMA score, in the UTHEVER group whereas there was a noteworthy rise in the placebo group, demonstrating the anti-aging effect of Uthever as in its absence, the parameters worsened</span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''></span></p><p style=''line-height:1.7;text-align:left;text-indent:0;margin-left:0;margin-top:0;margin-bottom:0''><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''></span><img src=''https://my-live-01.slatic.net/p/a27d8e1cde5c922aecfe377e3c70f1ac.jpg'' style=''width:960px;height:1280px;display:inline;vertical-align:middle''/><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''> </span><img src=''https://my-live-01.slatic.net/p/339abefd13aac4b4115f22348c4b0f09.png'' style=''width:374px;height:375px;display:inline;vertical-align:middle''/><span style=''font-weight:bold;color:rgb(68, 68, 68);background-color:rgb(229, 241, 248);font-size:10.5pt''> </span></p></article>