HE4 + CA 125 Biomarkers for Ovarian Cancer Screening CA 125 is a biomarker found in greater concentration in ovarian cancer cells than other cells. HE4 or Human Epididymis Protein 4 is a biomarker to increase the sensitivity of CA 125 for the detection of ovarian cancer. The advantages of HE4 + CA 125 Biomarkers: • HE4 increases CA125 sensitivity for detecting Stage I/II of ovarian cancer • More accurate predictor of malignancy than just CA125 or just HE4 test alone • Better risk stratification for women presenting with pelvic mass |