Description
Manufacturer
Merck
Contents
Metformin HCl 500 mg, glibenclamide 5 mg
Indication
Glucovance contains a combination of glyburide and metformin. Glyburide and metformin are both oral diabetes medicines that help control blood sugar levels.
Glucovance is used to treat type 2 diabetes. This medicine is not for treating type 1 diabetes.
Glucovance may also be used for purposes not listed in this medication guide.
Instruction
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Gluconvance should be given with meals and should be initiated at a low dose, with gradual dose escalation as described below, in order to avoid hypoglycemia (largely due to glyburide), reduce GI side effects (largely due to metformin), and permit determination of the minimum effective dose for adequate control of blood glucose for the individual patient.
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Use Glucovance as directed by your doctor.
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If you miss a dose, take the missed dose as soon as you remember (be sure to take Glucovance with food). Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Drug interaction
Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, ACE inhibitors (such as captopril), oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates. Azole antifungals (fluconazole) also interact with Glucovance.
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