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Pathol Antiseptic-Germicide has one of the most widely used and trusted antiseptic germicide preparations in the world. It is highly effective against bacteria, germs and viruses, yet gentle to the skin, non-poisonous and non-staining. Its active ingredient, Chloroxylenol, is recognized by the US Environmental Protection Agency (EPA) No. 49403-1 as safe and effective against the spread of viruses like influenza virus. It is ideal for use as antiseptic in hospitals, clinics and in first aid, and in the simultaneous cleaning, disinfection, and deodourisation in homes, offices, etc.
 
It is a revolutionary hospital-grade nanoemulsive disinfectant cleaner, as evidenced by its “magic-milk” effect. Employing unique nanoemulsive technology, Pathol Liquid is effective on surfaces, and is particularly well suited for situations where harmful impacts on equipment and working surfaces cannot be tolerated as a cost of reducing microbiological risks. Unlike liquid bleaching agents and other popular commercial disinfectant products, it is a non-irrtating cleanser that is exceptionally convenient and economical to use. It contains no respiratory, ophthalmic or dermatological irritants and has a pleasant pine-phenolic scent.
 
Pathol Antiseptic-Germicide has the following features:

• Approved by Ministry of Health (MAL 20040183XC).
• Complied with HALAL requirements according to Islamic Law Reg. No. JAKIM (22.00) 492/2/P2435.
• Same germicidal effect – Rideal Walker Coefficient of 3.
• Produced under Good Manufacturing Practices (GMP) Standards.
• Kills HIV, Staph., Ecoli and many other viruses, bacteria and fungi without causing any adverse effects to surfaces, humans or the environment.
• Formulated with excellent detergent system.
• No toxic fumes.
• Non-flammable.
• Cleans and disinfects in one step.

 General Features
 

• Extremely High Performance – A multi-purpose antiseptic/disinfectant offering all-round protection as:
  • Antiseptic
  • Germicide
  • Bactericide
  • Virucide
  • Fungicide
  • Tuberculocide

 

• Comparative Effectiveness of Disinfectants

 

Active Ingredient	Disadvantages / Advantages
Chlorine and Chlorine Compound	● Extremely corrosive to metals. ● Very caustic to tissue. ● Rapidly inactivated by organic debris (blood, tissue, saliva, microbes) ● Fumes can be irritating. Can emit a carcinogenic gas if it comes in contact with formaldehyde, or is hyperchlorinated by hot water. ● Diluted solutions quickly lose their effectiveness.
Iodine and Iodophors	● Have relatively slow kill times. Dilutions and contact times are critical for efficacy. ● May dry and crack skin, possibly burn tissue with prolonged exposure. Toxic if ingested. ● Must be discarded and remixed daily, inactivated by hard water. ● Solutions can stain fabrics, plastics, and other synthetic materials ● Corrosive to metal and rubber. ● Some staff acquires extreme sensitivity and develops anaphylactic shock upon exposure.
Quaternary Ammonium Compounds (QAC’s) or Quats	● Not tuberculocidal, or virucidal against hydrophilic viruses. ● Action is markedly depressed in the presence of organic material. ● May cause respiratory problems. ● Cationic, incompatible with soap. ● Absorbed and/or neutralized by various materials (e.g. cotton, wool) that absorbs the active ingredients. ● Maybe inactivated by hard water. ● Many pathogens are resistant.
Peroxygens (Hydrogen Peroxide or Peracetic Acid)	● Oxidising properties can be corrosive to equipment. ● Can cause a pseudomembrance-like enteritis and colitis if not properly rinsed from surface. ● Unstable, particularly when diluted.
Chloroxylenol	● A hard surface, hospital-grade disinfectant cleaner. It is effective against a broad spectrum of bacteria, viruses and fungi to give maximum infection control efficacy. ● Non-staining, with no harmful residual fumes, vapours, or unpleasant smell. ● It is safe for the environment, with no need for biohazard disposal. ● May dry and crack skin, possibly burn tissue with prolonged exposure. Toxic if ingested. ● Non-caustic, non-corrosive, non-carcinogenic. ● Chosen for its safety, proven efficacy, convenience, versatility and value.

 

Property	Chlorine	Iodine	Quats	Chloroxylenol
Effective against yeast	Yes	Some	Yes	Yes
Effective against fungi	Yes	Yes	Some	Yes
Effective against viruses	Yes	Some	Some	Yes
Effective against Gram +ve	Some	Yes	Yes	Yes
Effective against Gram -ve	Some	Yes	Some	Yes

 

• Fast Acting & Effective: Kills germs, bacteria and viruses without causing any adverse effects to surfaces, human and the environment. Clinical and lab tests have proven that it is a fast disinfectant cleaner against microbes on contaminated surfaces, yet gentle to the skin.

 
Chloroxylenol has been used successfully as an effective antimicrobial disinfectant ingredient for over 100 years, both in USA and Europe. It has demonstrated efficiency against Gram-negative and Gram-positive bacteria (Maris, 1955; McDonnell and Russel, 1999), a wide variety of fungal organisms (Ghannoun and Rice, 1999; Giulianna et al., 1999), and against RNA and DNA viruses (Wood and Payne, 1998). Spanning a period between the early 1940’s through the 1990’s, testing showed Chloroxylenol to have little or no toxicity in vitro by almost any route (oral, dermal, inhalation, and ingestion). Multiple toxicity studies have been submitted to the US FDA (OTC) section.
 

• Physical Properties
  • A clear, sparkling, amber-coloured liquid
  • Turns white when added into water (its “magic-milk” effect)
  • Pleasant pine-phenolic smell
  • Activity over a broad pH and temperature range (pH 4 – 12)
  • Effective in hard water
  • Great ease in handling
  • Can be fogged or sprayed
  • Non-corrosive and non-staining to metals, alloy plastics, synthetics, rubber, glass and painted surfaces.

EFFICACY

Chloroxylenol, the active ingredient in Pathol Antiseptic-Germicide has a broad spectrum of microbiocidal activity against every vegetative micro-organism tested to date. Fungi, gram-positive bacteria, and gram-negative bacteria are all controlled.
 

ORGANISM	MINIMUM INHIBITORY CONCENTRATION	MIC (ppm)
Bacteria:
Pseudomonas aeruginosa	1:1,000	1,000
Pseudomonas putida	1:1250	800
Proteus vulgaris	1:10,000	100
Escherichia coli	1:20,000	50
Staphylococcus aureus	1:100,000	10
Aeromonas hydrophilia	Pasteurella multocida
Bordetella avium	Salmonella choleraesuis
Campylobacter jujuni	Salmonella enteritidus
Corynebacterium sepedonicum	Salmonella sp
Klibsiella pneumoniae	Serovar pullorum
Listeria monocyogenese	Steptococcus suis
Fungi:
Aspergillus niger	1:5,000	200
Penicillium mineoluteum	1:1,000	1000
Fusarium solani	1:5,000	200
Geotrichum candidum	1:5,000	200
Virus:
Adenovirus Type 2	Marek’s Disease (JM-V)
Avian Reovirus	Porcine rotavirus
Infectious bronchitis	Pseudorabies virus
Infectious larynogotracheitis	Gastroenteritis virus
Influenza A2	Vaccinia
Herpes simplex Type 1 & 2
Yeast:
Candida albicans	1:20,000	50

Dilution Rates
 
Routine disinfection – dilute 1:100 (10ml per litre of water) to 1:200 (5ml per litre of water)
On earth floor – dilute 1:50 (20ml per litre of water)
Drinking water in poultry – dilute 1:1000 (1ml per litre of water)
 
ENVIRONMENTAL ACCEPTABILITY
The active ingredient, Chloroxylenol, readily degrades in rivers, sewage and activated sludge. It has a biodegradability of 70% after 7 days with the degradation products of xylenols and unchanged toxicity.

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