Kombiglyze XR 5/1000mg

Kombiglyze XR 5/1000mg

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Manufacturer
AstraZeneca
 
Contents
Saxagliptin 5 mg, metformin HCl extended-release 1,000 mg
 
Indication
Adjunct to diet & exercise to improve glycemic control in adults w/ type 2 diabetes mellitus.
 
Instruction
Should be taken with food: Take w/ evening meal. Swallow whole, do not chew/crush.
 
Drug interaction
Increased saxagliptin plasma concentrations w/ strong CYP3A4/5 inhibitors (eg, ketoconazole, itraconazole, atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, clarithromycin, telithromycin, nefazodone). Increased metformin levels w/ cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, vancomycin). Thiazides & other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, OC, phenytoin, nicotinic acid, sympathomimetics, Ca-channel blockers & INH may predispose to hyperglycemia & may lead to loss of glycemic control.

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