Manufacturer
Merck Sharp & Dohme
Contents
Simvastatin
Indication
Treatment of high cholesterol
Instruction
May be taken with or without food: Avoid excessive consumption (>1 L/day) of grapefruit juice.
Drug interaction
Increased risk of myopathy with itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhinbitors, boceprevir, telaprevir, nefazodone, drugs containing cobicistat, gemfibrozil, cyclosporine, danazol, other fibrates (except fenofibrate), fusidic acid, amiodarone, verapamil, diltiazem, amlodipine, lomitapide, moderate CYP3A4 inhibitors, niacin (≥1 g daily), colchicine. Increased plasma conc & risk of myopathy w/ breast cancer resistant protein (eg, elbasvir, grazoprevir) & transport protein OATP1B1 inhibitors. Increased plasma levels of HMG-COA reductase inhibitory activity w/ grapefruit juice. Potentiated effect of coumarin anticoagulants.
Malaysia
