Manufacturer
KOTRA PHARMA (M) SDN. BHD.
Contents
Glimepiride
Indication
Type 2 diabetes mellitus.
Instruction
Should be taken with food. Take immediately before or during breakfast, or the 1st main meal of the day. Do not skip meals.
Drug interaction
Increased hypoglycaemic effect with NSAIDs (e.g. phenylbutazone), insulin, oral antidiabetics (e.g. metformin), salicylates, fluoxetine, anabolic steroids and androgens, antibiotics (e.g. chloramphenicol, sulphonamides, tetracyclines, quinolones, clarithromycin), coumarin anticoagulants, disopyramide, fibrates, ACE inhibitors, MAOIs, allopurinol, probenecid, sulfinpyrazone, cyclophosphamide, fluconazole and pentoxifylline. Decreased hypoglycaemic effect with oestrogens, oral contraceptives, thiazide diuretics, glucocorticoids, phenothiazine derivatives (e.g. chlorpromazine), sympathomimetics (e.g. epinephrine, albuterol, terbutaline), nicotinic acid (high doses) and nicotinic acid derivatives, laxative (long term use), phenytoin, diazoxide, glucagon, barbiturates, rifampicin and isoniazid. Signs of hypoglycaemia may be reduced or absent in patients taking sympatholytic drugs (e.g. ß-blockers, clonidine, guanethidine, reserpine). May cause severe hypoglycaemia with miconazole.
Malaysia
