Description
This reagent is an in vitro diagnostic medical device (IVDMD) for professional use. PALERM is used to treat human red blood cells with papain in immunohaematology.
Principle Overview
Papain, a proteolytic enzyme derived from papaya (Carica papaya), induces a marked decrease in the electronegative charge on the surface of red blood cells enabling their agglutination by normally 'non-agglutinating' antibodies in saline medium.
The method used is based on the principle of haemagglutination. Red blood cells bearing an antigen, pretreated with papain, agglutinate in the presence of the corresponding antibodies.
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