Manufacturer
PFIZER IRELAND PHARMACEUTICALS
Contents
Sirolimus
Indication
Prophylaxis of organ rejection in patients receiving renal transplants in combination w/ cyclosporine & corticosteroids.
Instruction
May be taken with or without food: Take consistently either always w/ or always w/o meals. Avoid grapefruit juice.
Drug interaction
Increased levels w/ CYP3A4 & P-gp inhibitors (eg, diltiazem, nicardipine, verapamil, clotrimazole, fluconazole, itraconazole, ketoconazole, voriconazole, clarithromycin, erythromycin, telithromycin, troleandomycin, cisapride, metoclopramide, bromocriptine, cimetidine, cyclosporine, danazol, ritonavir, indinavir, boceprevir, telaprevir, grapefruit juice). Decreased levels w/ CYP3A4 & P-gp inducers (eg, carbamazepine, phenobarb, phenytoin, rifabutin, rifampicin, rifapentine, St. John's wort). Rhabdomyolysis w/ HMG-CoA reductase inhibitors, fibrate & cyclosporin. Vaccines.
Malaysia
