Manufacturer
NOVARTIS PHARMA STEIN AG
Contents
Per 5/320 mg tab Amlodipine besylate 5 mg, valsartan 320 mg.
Indication
Essential HTN in patients whose BP is inadequately controlled by monotherapy.
Instruction
May be taken with or without food.
Drug interaction
Amlodipine: Increased exposure of simvastatin. Increased plasma conc w/ CYP3A4 inhibitors. Valsartan: Concomitant use w/ K supplements, K-sparing diuretics, salt substitutes containing K or other drugs that increase K levels. Concomitant use of angiotensin II antagonist w/ NSAIDs may attenuate antihypertensive effects. Furthermore, increase worsening of renal function in vol-depleted or w/ compromised renal function elderly patients. Co-administration of inhibitors of uptake transporter (rifampin, ciclosporin) or efflux transporter (ritonavir) may increase systemic exposure to valsartan.
Malaysia
