Manufacturer
INTAS PHARM LTD
Contents
Fluorouracil
Indication
Colorectal cancer, Pancreatic carcinoma, Gastric cancer, Breast cancer,
Instruction
Administer via IV by Healthcare Personnel.
Drug interaction
Increased INR with warfarin. May increase the plasma concentration of phenytoin. Cimetidine may increase the plasma concentration of fluorouracil. May increase risk of toxicity with other cytotoxic agents used in combination with chemotherapy or in radiation therapy. Anti-tumour efficacy or toxicity may be altered by metronidazole, allopurinol. Increased risk of agranulocytosis with clozapine.
Potentially Fatal: Nucleoside analogues (e.g. brivudine, sorivudine) increases plasma concentration of fluorouracil, resulting in toxicological reactions. Concurrent administration of live vaccines may potentially cause serious infections.
Malaysia
