Manufacturer
Janssen
Contents
Trabectedin
Indication
Advanced soft tissue sarcoma after failure of anthracyclines & ifosfamide. Relapsed platinum-sensitive ovarian cancer in combination w/ pegylated liposomal doxorubicin (PLD).
Instruction
Yondelis must be administered under the supervision of a physician experienced in the use of chemotherapy. Its use should be confined to personnel specialized in the administration of cytotoxic agents.Recommended Starting Dose: 1.5 mg/m2 body surface area, administered as an IV infusion over 24 hrs with a 3-week interval between cycles.Administration through a central venous line is strongly recommended
Drug interaction
Potent CYP3A4 inhibitors (oral ketoconazole, fluconazole, ritonavir, clarithromycin, aprepitant; dexamethasone; potent CYP3A4 inducers (rifampicin, phenobarb, St. John's wort); P-gp inhibitors (cyclosporine, verapamil).
Malaysia
