Manufacturer
GlaxoSmithKline Manufacturing S.p.A
Contents
Topotecan HCl
Indication
Small cell lung cancer
Instruction
May be taken with or without food. Swallow whole do not open/chew/crush.
Drug interaction
Increased clearance with phenytoin. G-CGF to be given 24 hr after completion of treatment with topotecan as concurrent admin may prolong duration of neutropenia. Increased bone marrow supression with other cytotoxic drugs (e.g. cisplatin) so dose reduction may be needed.
Malaysia
