Manufacturer
DUOPHARMA (M) SDN. BHD.
Contents
Domperidone
Indication
Acute treatment of nausea and vomiting
Instruction
Should be taken on an empty stomach. Take 15-30 min before meals.
Drug interaction
May increase risk of QT interval prolongation with azithromycin, roxithromycin, and with bradycardia- and hypokalaemia-inducing drugs. May decrease bioavailability with antacids or antisecretory agents. May antagonise the prokinetic effects of anticholinergics (e.g. bromocriptine). Increased plasma concentrations of levodopa.Potentially Fatal: Increased risk of QT interval prolongation with potent CYP3A4 inhibitors (e.g. protease inhibitors, systemic azole antifungals, clarithromycin, telithromycin, nefazodone), moderate CYP3A4 inhibitors (e.g. diltiazem, verapamil), and QT-prolonging drugs (e.g. quinidine, disopyramide, dofetilide, amiodarone, haloperidol, pimozide, citalopram, erythromycin, levofloxacin, pentamidine, halofantrine, lumefantrine, cisapride, dolasetron, mizolastine, mequitazine, toremifene, vandetanib, vincamine, bepridil, methadone; apomorphine [unless the benefit outweighs the risk and recommended precaution is strictly fulfilled]).
Malaysia
